Why some women don't have enough breastmilk for baby: Important role of insulin in making breast milk identified
July 5, 2013 — Why do so many mothers have difficulty making enough milk to breastfeed? A new study by scientists at Cincinnati Children's Hospital Medical Center and the University of California Davis adds to their previous research implicating insulin's role in lactation success.
Share This:
The study is the first to describe how the human mammary gland becomes highly sensitive to insulin during lactation. It is also the first study to get an accurate picture of how specific genes are switched on in the human mammary gland during lactation.
The researchers used next generation sequencing technology, RNA sequencing, to reveal "in exquisite detail" the blueprint for making milk in the human mammary gland, according to Laurie Nommsen-Rivers, PhD, RD, IBCLC, a scientist at Cincinnati Children's and corresponding author of the study, published online in PLOS ONE, a journal of the Public Library of Science.
Nommsen-Rivers' previous research had shown that for mothers with markers of sub-optimal glucose metabolism, such as being overweight, being at an advanced maternal age, or having a large birth-weight baby, it takes longer for their milk to come in, suggesting a role for insulin in the mammary gland. The new research shows how the mammary gland becomes sensitive to insulin during lactation.
For a long time, insulin was not thought to play a direct role in regulating the milk-making cells of the human breast, because insulin is not needed for these cells to take in sugars, such as glucose. Scientists now, however, appreciate that insulin does more than facilitate uptake of sugars.
"This new study shows a dramatic switching on of the insulin receptor and its downstream signals during the breast's transition to a biofactory that manufactures massive amounts of proteins, fats and carbohydrates for nourishing the newborn baby," says Dr. Nommsen-Rivers.
"Considering that 20 percent of women between 20 and 44 are prediabetic, it's conceivable that up to 20 percent of new mothers in the United States are at risk for low milk supply due to insulin dysregulation."
Dr. Nommsen-Rivers and her colleagues were able to use a non-invasive method to capture mammary gland RNA -- a chain of molecules that are blueprints for making specified proteins -- in samples of human breast milk. They then created the first publicly accessible library of genes expressed in the mammary gland based on RNA-sequencing technology.
This approach revealed a highly sensitive portrait of the genes being expressed in human milk-making cells. They discovered an orchestrated switching on and off of various genes as the mammary gland transitions from secreting small amounts of immunity-boosting colostrum in the first days after giving birth to the copious production of milk in mature lactation.
In particular, the PTPRF gene, which is known to suppress intracellular signals that are usually triggered by insulin binding to its receptor on the cell surface, may serve as a biomarker linking insulin resistance with insufficient milk supply. These results lay the foundation for future research focused on the physiological contributors to mothers' milk supply difficulties.
Now that they've demonstrated the significance of insulin signaling in the human mammary gland, they are planning a phase I/II clinical trial with a drug used to control blood sugar in type 2 diabetes to determine whether it improves insulin action in the mammary gland, thus improving milk supply. While a drug is not an ideal way to solve the problem of sub-optimal glucose metabolism impairing breastfeeding, according to Dr. Nommsen-Rivers, it is excellent for establishing proof-of-concept through the use of a placebo controlled randomized clinical trial.
"The ideal approach is a preventive one," she says. "Modifications in diet and exercise are more powerful than any drug. After this clinical trial, we hope to study those interventions."
Dr. Nommsen-Rivers began her quest to understand why so many U.S. mothers today struggle with low milk supply when she was a doctoral student at the University of California Davis.
The lead author of the study is Danielle Lemay, PhD, of the University of California Davis Research Center.
Welcome to SUV System Ltd!
SUV System Ltd is ISO 90012008 Certified electronics distributor with 10 years of experiences.
We have built up long term business relationship with about many companies which are stockers and authorized agents. we have a steady and reliable supply to meet customer's demands to the greatest extent .Confidently, we are able to lower your cost and support your business with our years of professional service.
SUV System Ltd is Electronic Components Distributor Supplies,Find Quality Electronic Components Supplies Products IC(Integrated Circuits),Connectors,Capacitor,Resistors,Diodes,Transistors,LED at Suvsystem.com. Sourcing Other Energy, Environment, Excess Inventory Products from Manufacturers and Suppliers at Suvsystem.com
Electronic Components distributor:http://www.suvsystem.com
Connectors Distributor:http://www.suvsystem.com/l/Connectors-1.html
IC Distributor:http://www.suvsystem.com/l/IC(Integrated-Circuits)-1.html
LED Distributor:http://www.suvsystem.com/l/LED-1.html
Capacitor Distributor:http://www.suvsystem.com/l/Capacitor-1.html
Transistor Distributor:http://www.suvsystem.com/l/Transistors-1.html
Resistor Distributor:http://www.suvsystem.com/l/Resistors-1.html
Diode Distributor:http://www.suvsystem.com/l/Diodes-1.html
SUV System Ltd insists on the managing faith ofsincereness,speciality,foresight, win-win,so we build up stable-relationship customers located all over the world, including the States, Europe, Argentina, UAE, Malaysia, Australia,and India etc
we are focus on the following fields,and hope we can help you.
AVX High Precision Chip Fuses Current Sensors VISHAY Renesas parts PANASONIC Schottky Freescale Semiconductor DIODES IR transistor MOTOROLA chip Filter saws PANASONIC TOSHIBA Diodes Inc Vishay resistors NXP Metal Can Packages Ligitek LED Voltage Regulators INFLNEON About US IR Fairchild Semiconductor NEC News Thin Film Other Parts Fast Recovery ON Zener MAXIM Transistors Freescale Resistor Arrays Microchip IC Thick Film TI IC HARRIS TDK
http://www.suvsystem.com/a/3524.aspx
No comments:
Post a Comment